Molecular
Basis of Water, Acid and Solute transport (Investigators:
Ausiello, Breton, Brown, Cantiello, Ercolani, Marshansky, Sever,
van Hoek)
Renal injury and
Repair (Investigators: Adair, Arnaout,
Christmas, Soberman, Lin)
Developmental
Biology and Genetics (Investigators:
Arnaout, Drummond, JW Xiong)
Clinical Epidemiology (Investigators:
Bhan, Thadhani, Wong)
Vascular Biology
and Hypertension (Investigators:
Arnaout, Haupert, Kang, JW Xiong)
Inflammation, Autoimmunity
and Transplantation Biology (Investigators:
Adair, Arnaout, Goes, Niles, Nikolic, Tolkoff-Rubin, Sachs, Sykes, JP Xiong)
Genomics,
Proteomics applied
to diabetes mellitus and cancer (Investigators: Arnaout, Thadhani)
Receptor Dynamics (Investigators: Adair, Arnaout, JP Xiong)
Medical Informatics (Investigators: Bahn)
A
major new basic research effort based in the Nephrology Division
is an MGH Structural Biology Program aimed at determining the three-dimensional
structure of molecules, in order to gain more insight into their
function with the potential of developing antagonists that could
be used therapeutically. A crystallography facility equipped with
a state-of-the-art automated X-ray Imaging System (R-AXIS IV),
X-ray Generator, Silicon Graphics computers and protein modeling
software is staffed by three crystallographers and has been in
full operation since March 1 1998. Active
clinical and translational research programs in hypertension, preeclampsia,
transplantation, dialysis and outcomes research complement and
extend the basic science programs of the Nephrology Division. |
Specific
projects include:
Function,
regulation and trafficking of aquaporin water channels, proton
pumping ATPases, cystic fibrosis transmembrane conductance
regulator (CFTR), sodium channels and the vasopressin V2 receptor;
Role of dynamin
in vesicle trafficking
Mechanisms
of renal ischemic injury and repair
Biology of
TGFß and its receptors
Role of the
cytoskeleton in ion transport
Chemical
structure of hypothalamic Na-K-ATPase inhibitor
Role of G
proteins in membrane protein targeting in epithelium
Monitoring receptor signaling by intramolecular FRET
Molecular
basis of leukocyte adhesion and its role in inflammation and
injury
Podocyte
biology
Transcription
factors involved in myelomonocytic differentiation
Crystal structure
of adhesion and immune-related proteins
Role of anti-neutrophil
cytoplasmic antibodies in autoimmune vasculitis
Genetic analysis
of kidney development in zebrafish
Molecular
and cell biology of autosomal polycystic kidney disease (ADPKD)
Branching
morphogenesis
Proteomic
and metabolomic analysis of diabetic nephropathy
Role of fish oil in
cardiovascular and renal disease
Metabolic bone disease
Molecualr basis of
allograft rejection and tolerance |
